9/14/2023 0 Comments Trazodone for insomnia![]() One review suggested trazodone might be helpful in combatting the side effects of SSRIs. Studies suggest that trazodone is able to effectively reduce cortisol levels during sleep, thus calming the central nervous system down and resulting in longer sleep times, increased deep sleep, and better sleep quality. (Doxepin elixir – another sleep aid often used in ME/CFS and FM appears to do the same thing.).ĭoxepin Elixir (Sinequan, Silenor) for ME/CFS and Fibromyalgia Trazodone appears to be achieving this by reducing night-time cortisol levels. Twelve years later, another small study reported that trazodone was more effective than CBT-I in people who exhibit “physiological hyperarousal (ie, activation of the stress system)” during sleep. A small 2008 study found that while CBT improved sleep time and latency (the ability to fall asleep quickly) that CBT plus trazodone resulted in a further increase in the restorative period of deep, slow-wave sleep in people with depression. Trazodone may also enhance the benefits of mindfulness practices such as cognitive-behavioral therapy (CBT) in some people. Health Rising is almost entirely community supported. Small donations, large donations – they all add up. If you’re jazzed by any of these please, if you’re able, support Health Rising in a way that works for you. Health Rising’s Quickie Summer Donation Drive is On! It also reported that Trazodone increases the”duration of deep sleep, which is associated with better sleep quality as assessed by patients”. insomnia that occurs later in the night or morning. On the other hand, it is “very effective” in treating “sleep-maintenance” insomnia i.e. ![]() A recent review of trazodone (and other antidepressants as well as anticonvulsants and antipsychotics) reported that it and the other drugs had “a beneficial effect on sleep architecture” but may suppress REM sleep.Ī 2021 review reported that trazodone is less effective than hypnotics in treating sleep-onset insomnia (i.e., the inability to fall asleep) and when used for this purpose should be taken at least an hour before going to sleep. Mathew Walker has inveighed against the use of sleep drugs because he reports that they don’t improve sleep architecture and are associated with detrimental long-term effects. Trazodone may also be helpful with erectile dysfunction. This finding jives with findings indicating that inflammation triggers depression in some people and that some antidepressants may be reducing neuroinflammation. It also protected nerve cells from damage due to neurotoxicity apparently by activating 5-HT1A receptors and blocking 5-HT2A/C serotonin receptors. Trazodone’s unusual structure prompted lead Italian researchers to check out what impact it was having on neurons in the central nervous system.Īdding trazodone to human astrocytes (brain neurons) prior to subjecting them to an inflammatory trigger stopped the effects of a powerful pro-inflammatory cytokine called TNF-a in its tracks and reduced the activity or expression of other pro-inflammatory cytokines. Trazodone is a triazolopyridine derivative that is structurally more closely related to other triazolopyridine-derived drugs than the drugs that make up major classes of antidepressants. Neuroinflammation Reducer? Trazodone may have an unexpected trip up its sleeve. Trazodone is classified as a “weak histamine antagonist” but its histamine blocking effects could conceivably be helpful in people with mast cell activation syndrome (MCAS). That’s potentially an important asset for people with ME/CFS/FM whose sleep gets disrupted by the arousal of the HPA axis. ![]() By inhibiting the reuptake of serotonin and blocking the histamine and alpha-1-adrenergic receptors, trazodone reduces levels of neurotransmitters (serotonin, noradrenaline, dopamine, acetylcholine, and histamine) that are associated with arousal. for insomnia.Īrousal Combatter – Trazodone is mostly known as a serotonin antagonist and reuptake inhibitor (SSRI). In fact, low-dose trazodone is reportedly the second most commonly used sleep aid used in the U.S. A drug that was produced for use as an antidepressant drug but which is almost always used in its low dose formulation as a sleep aid in chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM). ![]()
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